Back in April 2017, Microsoft announced the release of support for Modern Authentication for the Skype for Business Online PowerShell Module. Adding Modern Authentication introduces new scenarios where multi-factor authentication (MFA) can be used for authenticating remote PowerShell sessions out to Skype for Business Online. Using MFA for authentication for PowerShell sessions provides another layer of security for administrator accounts when managing Office 365 workloads.

Read my full article over at the Perficient Microsoft Blog:

http://blogs.perficient.com/microsoft/2017/10/skype-for-business-online-enabling-mfa-for-powershell-sessions/